Home
Modelling suggests blood group incompatibility may substantially reduce SARS-CoV-2 transmission

Modelling suggests blood group incompatibility may substantially reduce SARS-CoV-2 transmission


Share Button

Several independent datasets suggest blood type A is over-represented and type O under24 represented among COVID-19 patients. Here, I model a scenario in which ABO transfusion incompatibility reduces the chance of a patient transmitting the virus to an incompatible recipient. Comparison of model outputs to published data on COVID-19 prevalence indicates that if this scenario holds true, ABO incompatibility may reduce virus transmissibility by 60% or more. Paradoxically, however, targeted vaccination of either high-susceptibility type A or “super spreader” type O individuals is less effective than random vaccination at blocking community spread of the virus. Instead, the key is to maintain blood type diversity amongst the remaining susceptible individuals. I stress that these results illustrate a theoretical model of ABO blood group interaction with virus transmission and require confirmation by observation.

Share Button

About The Author

Rhesusnegative.net

Disclaimer: This blog, all of its content and all of my posts are for Entertainment Purposes Only. Approval of comments does not equal agreement with content. Read at your own risk. Please note that comments will not be approved unless you use your real name. You can use first name only, if no one else has commented under that name before. Otherwise use first name and last initial. If that has been taken, use your full first and last name. No exceptions. Thank you for understanding.

2 Comments

  1. Catherine O November 15, 2020 Reply

    Seeking Clarity
    Hi Mike;
    In your report, both in writing here on your website, and verbally, in your videos on YouTube, you report our blood type may reduce chances of transmission (spreading), or contracting Covid-19. There is no clarification distinguishing between ABO positive or negative. Are you referring to ABO positive only, or ABO negative? Which group, or is it both groups? If both, are there differences statistically between the ABO positive and ABO negative groups? It would be so helpful to make that distinction clear…or explain why this isn’t stated.

  2. Mike DammannAuthor November 16, 2020 Reply

    Hi Catherine,
    this particular study doesn’t examine the Rh factor. I hope there will be plenty of studies coming that will. We have indicators from previous studies that Rh negatives enjoy protection from infection, so it is very likely that an O+ for example cannot easily transmit the virus to an O- like they could to another O+.
    We do need data though to confirm and there is none at this time. Other questions:
    Are Rh negatives more likely to transmit the virus to other Rh negatives and possibly Rh positives than Rh positives can?
    We are just starting to get familiar with the structure of the transmission and all these questions will have to be answered in time. As soon as I get more information, I will post the study immediately on the blog.

    We found slightly increased infection prevalence among non-O types. Risk of intubation was decreased among A and increased among AB and B types, compared with type O, while risk of death was increased for type AB and decreased for types A and B. We estimated Rh-negative blood type to have a protective effect for all three outcomes.

    https://www.rhesusnegative.net/staynegative/testing-the-association-between-blood-type-and-covid-19-infection-intubation-and-death/

Add a Comment

Your email address will not be published. Required fields are marked *

This site uses Akismet to reduce spam. Learn how your comment data is processed.