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Association of ABO blood group and secretor phenotype with severe COVID‐19

Association of ABO blood group and secretor phenotype with severe COVID‐19

 Rhesusnegative.net4
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Access the PDF file: https://www.rhesusnegative.net/staynegative/wp-content/uploads/2020/11/trf.16130.pdf

I have previously promised to look more into the potential association between non-secretor status and COVID-19. Here is a new study:

Association of ABO blood group and secretor phenotype with severe COVID‐19

I will highlight the part I consider quite interesting for now:

Although there was no significant association with the risk of thrombotic events (stroke, myocardial infarction, and venous thromboembolism), remarkably the nonsecretor phenotype was associated with lower in‐hospital mortality (adjusted OR, 0.53; 95% CI, 0.32‐0.83; P = .014). Mortality data according to O vs non‐O blood group and rs601338 variant are shown in Figure 1. Therefore, secretion of A/B antigens may promote COVID‐19 progression, but further studies will be necessary to confirm the protective effect of nonsecretor phenotype.

While the forum settings are private at this current time, I reserve the right to change that in the future:

http://rhesusnegative.net/rhnegativeforum/index.php/topic,72.msg332.html#new

Does anybody reading this have data on secretor and non-secretor frequencies among Rh negative ABO types specifically?

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4 Comments

  1. Ken November 11, 2020 Reply

    it was a small study, but here it is:

    Frequency of ABH secretors and non secretors: A cross sectional study in Karachi
    Pak J Med Sci. 2014 Jan-Feb; 30(1): 189–193.
    doi: 10.12669/pjms.301.4194 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3955570/

    “Methods: Blood and saliva samples were randomly collected from one hundred and one (n=101) healthy adult students (76 male, 25 female) ranging in age from 15 to 40 years. Their ABO and Rhesus blood groups were determined by conventional methods, and their secretor status was studied by hemagglutination inhibition method of saliva.”

    “In Rh (D) positive individuals 63.6% were secretors and 36.4% were non-secretors while Rh (D) negative individual were 76.9% secretors and 23.1% were non-secretors as shown in Table-III. Distribution of ABO blood groups and frequency of secretor status in A, B, AB and O blood groups in the study are shown separately in Table-IV.”

    Secretor status: https://en.wikipedia.org/wiki/Secretor_status

    Blood Types
    “How can I figure out if I am a secretor or non-secretor? What does this mean in everyday life?”
    – A curious adult from Georgia – May 29, 2019
    https://genetics.thetech.org/ask-a-geneticist/secretor-status-and-blood-type

    • Mike DammannAuthor November 11, 2020 Reply

      Interesting. I would have expected it to be the other way around as so many Rh negatives around us turn out non-secretors. The study is small, so who knows what a larger study will reveal.

  2. Lesley November 16, 2020 Reply

    Thats crazy, I thought we were probably non-secretors. The last line on the page posted here says secretors have been robustly linked to protection against other RNA viruses, so it makes sense.

  3. Ken November 16, 2020 Reply

    – another middle eastern study – on secretor status that looked at Rh(D) positive & negative results –

    Higher frequency of secretor phenotype in O blood group – its benefits in prevention and/or treatment of some diseases – Int J Nanomedicine. 2010; 5: 901–905. – Published online 2010 Nov 2. doi: 10.2147/IJN.S13980 – Mohamad Salih Jaff – https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2990383/

    Materials and methods
    “” Seven hundred and sixty-two apparently healthy unrelated adults (480 men and 282 women) were randomly selected and asked to volunteer for this study, after they were informed about its aim. This study was carried out in Hawler Teaching Hospital Laboratory, Erbil, Kurdistan Region, Iraq, in the period between January 2008 and May 2010. “”

    “” ABO and Rhesus blood grouping was performed on saline-washed red blood cells using commercial antisera kits: monoclonal anti-A, anti-B antisera (Plasmatec Laboratory Products Ltd., Bridport, Dorset, UK), and monoclonal anti-H antiserum (Seraclone, Biotest, Dreieich, Germany) by the standard conventional hemagglutination technique. “”

    Results
    “” In Rh(D)-positive individuals, 76% were secretors and 24% were nonsecretors, while in Rh(D)-negative individuals 77% were secretors and 23% were nonsecretors (Table 3). “”

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