The Rh Negative Blog

Association of ABO blood group and secretor phenotype with severe COVID‐19

I have previously promised to look more into the potential association between non-secretor status and COVID-19. Here is a new study:

Association of ABO blood group and secretor phenotype with severe COVID‐19

I will highlight the part I consider quite interesting for now:

Although there was no significant association with the risk of thrombotic events (stroke, myocardial infarction, and venous thromboembolism), remarkably the nonsecretor phenotype was associated with lower in‐hospital mortality (adjusted OR, 0.53; 95% CI, 0.32‐0.83; P = .014). Mortality data according to O vs non‐O blood group and rs601338 variant are shown in Figure 1. Therefore, secretion of A/B antigens may promote COVID‐19 progression, but further studies will be necessary to confirm the protective effect of nonsecretor phenotype.

While the forum settings are private at this current time, I reserve the right to change that in the future:

http://rhesusnegative.net/rhnegativeforum/index.php/topic,72.msg332.html#new

Does anybody reading this have data on secretor and non-secretor frequencies among Rh negative ABO types specifically?