COVID-19 deaths: 1 out of 45 Rh- and 1 out of 8 Rh+ patients (NYP/CUIMC)

Rhesusnegative.net

5 years ago

UPDATE:

Protective associations between Rh negative blood groups and SARS-CoV-2 infection and death

The latest revision.

Summary demographics for SARS-CoV-2-tested individuals at NYP/CUIMC, stratified by blood group (BG). N is the number of individuals having the given blood type who have a recorded test (positive or negative) for SARS-CoV-2, and reports percentages relative to all blood groups. Rh-stratified blood groups are individuals from the ABO blood groups (eg. for N, A-negative + A-positive = A). Med. age gives the median age within each group. COV+ and COV- give percentages relative to all tested individuals for that blood group. COV+/Intubated (intub.) and COV+/Died report percentages relative to COV+ individuals. Risk factors (hypertension (HTN), cardiovascular (CV) diseases mellitus (DM), respiratory (resp) diseases, diabetes, overweight status (OW)) are reported as percentages relative to all tested individuals of that blood group. The general population (gen) column reports counts and percentages by blood group relative to the non-SARS-CoV-2-tested individuals from NYP/CUIMC with recorded blood type. The final row (Σ) gives combined results without stratification by blood type

Among the patients with Rh(D) positive blood groups, 1 in 8 died.

Among the patients with Rh(D) negative blood groups, 1 in 45 died.

This is a significant difference, but since there were only 45 COVID-19 cases of people with Rh(D) negative blood groups with one (A-) dying, more studies are needed to confirm these results.

See the study:

https://www.rhesusnegative.net/staynegative/wp-content/uploads/2020/05/2020.04.08.20058073v1.full_.pdf

In this study we found evidence for association between blood groups and COVID-19. Using data from NYP/CUIMC, we found the odds of COVID-19 positive vs negative test results were increased in blood groups A and decreased in blood groups O, consistent with previous results from Wuhan and Shenzhen. While Rh negative blood types are rare, we find evidence of association only for Rh positive blood groups. Though few AB individuals were included in our cohort, we discovered a new significant odds decrease for AB blood groups. In a meta-analysis of our data with data from Wuhan and Shenzhen reported by Zhao et al., we found a new significant COVID-19 odds increase for B blood groups compared to the general population. We demonstrated that the associations we found were not explained by confounding due to several known risk factors. Our results replicate previously-discovered associations between A and O blood groups and COVID-19, and we show novel associations between B, AB, and Rh blood groups.