Is haemophilia more common in people who are Rh(D) negative? One interesting thing is the high frequency of it in a family with high frequencies of O negative blood:
Haemophilia figured prominently in the history of European royalty in the 19th and 20th centuries. Britain’s Queen Victoria, through two of her five daughters, Princess Alice and Princess Beatrice, passed the mutation to various royal houses across the continent, including the royal families of Spain, Germany and Russia. Victoria’s son Prince Leopold, Duke of Albany, also suffered from the disease. For this reason, haemophilia was once popularly called “the royal disease”. Tests on the remains of the Romanov imperial family show that the specific form of haemophilia passed down by Queen Victoria was probably the relatively rare Haemophilia B.Inheritance by female carriersAlexandra Feodorovna (6 June 1872 – 17 July 1918) was Empress of Russia as the spouse of Nicholas II—the last ruler of the Russian Empire—from their marriage on 26 November 1894 until his forced abdication on 15 March 1917. A favourite granddaughter of Queen Victoria of the United Kingdom, Alexandra was like her grandmother, one of the most famous royal carriers of the haemophilia disease.
