Hemolytic disease of the newborn was first described in 1609 medical literature

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The first description of HDN is thought to be in 1609 by a French midwife who delivered twins—one baby was swollen and died soon after birth, the other baby developed jaundice and died several days later. For the next 300 years, many similar cases were described in which newborns failed to survive.

https://www.ncbi.nlm.nih.gov/books/NBK2266/#:~:text=The%20first%20description%20of%20HDN,which%20newborns%20failed%20to%20survive.

ABO incompatibility may reduce virus transmissibility by 60% or more