SARS-CoV-2 and mutation RT-qPCR test positivity correlation with ABO and Rh blood types

Studies show that there may be a relationship between ABO blood type and SARS-CoV-2 transmission. It was aimed to determine by investigating the blood type of patients whose one-step reverse transcription and real-time polymerase chain reaction (RT-qPCR) test were positive for SARS-CoV-2. ABO and Rh blood types of individuals whose RT-qPCR test was positive for SARS-CoV-2 were examined and an evaluation was made to identify whether there was a relationship between them or not. The blood type data of 44.928 SARS-CoV-2 positive RT-qPCR test results have been obtained. 17.656 (39.29%) were delta, 8048 (17.91%) were alpha, 800 (1.78%) were beta, and 3000 (6.67%) were omicrons while 15.424 (34.33%) SARS-CoV-2 positive mutation was found to be negative. Our study suggests that O and Rh (−) blood types may provide protection against delta, AB and Rh (+) blood types may hinder omicron infection while A and Rh (+) blood types may be more vulnerable to alpha and delta while B and Rh (+) are more sensitive to beta mutation. The molecular mechanism underlying the relationship between blood types and SARS-CoV-2 infection needs further molecular studies and multi-centered studies.