Lewis and ABO histo-blood types and the secretor status of patients hospitalized with COVID-19 implicate a role for ABO antibodies in susceptibility to infection with SARS-CoV-2
Rhesusnegative.net
Schematic illustration of mucosa cells with glycosylated structures and receptor–ligand interactions. Hormones, antibodies, as well as viruses and bacteria or their toxins, interact with oligosaccharide epitopes (glycoproteins) that serve as receptors or co-receptors. The suggested interference of ABO antibodies with SARS-CoV-2 targeting of host cells via angiotensin-converting enzyme 2 (ACE-2) receptor is indicated. Made with Biorender.com [Color figure can be viewed at wileyonlinelibrary.com]
Patients with blood type Lewis (a−b−) or O were significantly less likely to be hospitalized (odds ratio [OR] 0.669, confidence interval [CI] 0.446–0.971, OR 0.710, CI 0.556–0.900, respectively), while type AB was significantly more prevalent in the patient cohort (OR 1.519, CI 1.014–2.203). The proportions of secretors/nonsecretors, and Lewis a+ or Lewis b+ types were consistent between patients and controls. The analyzed blood groups were not associated with the clinical outcome as defined.
