This is a question I have been getting and unfortunately there is no information on it that can be used as evidence that there is a higher percentage of rh negatives amongst lupus patients.
When it comes to autoimmune issues in general, RhD negative subjects have increased the risk of developing of certain heart diseases, respiratory diseases and some immunity and autoimmunity related diseases, for example rheumatoid arthritis. The general pattern suggests that RhD negative subjects could have problems with autoimmunity, could be more resistant to infections of viral origin and could be less resistant to infections of bacterial origin. The variation of the oxygen tension in various organs and tissues could, of course, influence also other biological functions, including the functions of the immune system. This could explain why RhD negativity seems to be associated with neurological, mental health and immunological disorders.
(More here: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4619848/)
There is also a small study associating the blood type B antigen with lupus:
In 45 patients with SLE the frequency of groups B and AB exceeded that of the controls, the difference reaching the double of the standard error. The isoagglutinin titers were quite similar in the two series. There was no association of the disease with the frequency of the secretor type nor with the quantity of group substances or isoagglutinins present in saliva and urine. The isoagglutinin titers in the sera of non-secretors were low.
https://www.ncbi.nlm.nih.gov/pubmed/1241149
And then there are a few online discussions started by rh negative people wondering if there is a connection between lupus and rh negative blood:
lupus and people with rh- factor.
Lupus And RH Negative
if you have any information, please comment below to help us advance in terms of information not yet common knowledge.
The study is only based on 45 people with lupus … Think of the ration of people with rhesus negative blood .
How many negs are tested for lupus because they have symptoms … I have auto immune problems … How do you distinguish between the same thing happening due to overactive auto immune … The wide range of symptoms are the same … So I many negs,are tested for lupus . So this is why the question has been asked over and over again … Suspected lupus in rhesus negs … How the tests for lupus are done is important …
I noticed you had a few people comment on the facebook post that they or family member have lupus .
This is also a questions I’ve asked myself many times. I was 22 and healthy when I came down with something so painful I had never experienced before called Raynaud’s phenomenon that didn’t go away. A week passed and I went to the doctor thinking I was loosing my hands. They told me my hands would be fine, If I had an abortion. Abortion???? I’m Pregnant??? I was confused as I had taken the best precaution I knew how (condoms). I was very early, in fact only 2 weeks along. When the nurse came in she explained It was an RH-Negative pregnancy. I had no clue what this meant of course. She advised me that the baby’s blood did not match mine and I would more than likely miscarry anyway. I continued with the termination, and my hands returned to normal. A few months later I started developing severe joint pain and stiffness and the Raynaud’s. I just brushed it off until it became worse as a few more years passed, along with new symptoms and severe anxiety attacks. I decided it was time to check in with a doctor after googling my symptoms which lead me to believe I may have contracted lime disease since I was an avid hiker. The results came in. Doctor says…”You don’t have lime disease, its Lupus SLE.
I always had a hunch that My SLE was triggered from the RH- Negative pregnancy, and I simply wasn’t aware until my symptoms couldn’t be ignored anymore.