Most Europeans are carriers or Rh negative

8 Comments

1. Richard Youatt June 12, 2020 Reply

   A very helpful clarification ! Can you add some detail on Weak D and the different variants of Rh Neg?

2. Richard Youatt June 14, 2020 Reply

   There are certain key assumptions that have to be met for the Hardy Weinberg principle to be meaningful.
   See https://www.thoughtco.com/hardy-weinberg-equilibrium-definition-4157822.
   I am not convinced that the principle applies to Rh neg populations. A quick summary of the % Rh Pos to Rh Neg in your summary by country shows big differences, and then there are the even bigger differences within countries.

• Mike DammannAuthor June 15, 2020 Reply

  Partial-D seems very high in Africa, Weak-D in Asia.

3. Marie June 14, 2020 Reply

   Good to know this! I have 4 children of which 2 are RH- negative, & the other 2 are RH-positive! I was sure my ex husband was positive, since I myself am negative, but this means he must also carry the negative gene? He must be + –
   And I must carry only negative genes – – being RH-negative? Right?

4. Robin Pry June 16, 2020 Reply

   You have mentioned in prior posts that RH negative blood types migrate. I have not had a lot of time to research lately. My quest was to find origon. I know little, just trying to see prior to migration an origon. Our temperature is .5-1 degree lower than the average person placing us in a colder climate. Also trying to trace our unique genome mutations, and long family lines of RH negatives places us… Somewhere in Europe, north… Germany, norway, iceland, switzerland…But that’s just where my research leads…who knows really? Was reading about hyperborism race from Atlantis aka Antarctica the atlantians???? Someone else thinks we came from Antarcticaand we were once native of Atlantis ,over time was too frigid to sustain human life…I am frustrated, want facts and truth, I personally d I not believe we are from another planet…because if we were, our family would save us from this most certain crisis we all face today face today. And remove us from anarchy, social discourse, disease and a government that behaves like 2 yr olds…uncivilized and antisocial..world..

• Richard Youatt June 17, 2020 Reply

  On the same quest…am interested in any clues from genomics.
  My Y-DNA (strictly father-to-son) is U106 which points to Northern Europe as its most likely geographic are of mutation. Rh genes are however autosomal…with an approx 50% inheritance from each parent. That makes it hard to apply the Y-DNA and MtDNA (mother to daughter) research techniques. However, we do have some distinctly skewed global distribution patterns. Recent years have also brought detailed breakdown (molecular biology) of the sub-types of Rh Neg. “European” Rh Negs (i.e. in or from Europe) have significantly more RhD gene deletion than African Rh Negs (i.e. those in or from Africa). It may be possible to make some reasonable estimates for the date at which the RHD gene deletion took place for “Europeans”. The African mutations are probably older.

• Richard Youatt June 17, 2020 Reply

  Mike and others:

  Here is a link to some Japanese research on Rh Neg.

  https://dm5migu4zj3pb.cloudfront.net/manuscripts/119000/119543/cache/119543.1-20140626150552-covered-253bed37ca4c1ab43d105aefdf7b5536.pdf

  This contains serious hard facts and truths. This article is not behind a paywall.

  Other pieces, by the same author, on the use of genomics to understand the evolution of Rh genes are.

  For me, looking at what is known about RH Neg on this planet is a good place to start.

  Genomic evidence points the way.

• - Ken - June 17, 2020 Reply

  nice link…it’s interesting to see the similarity, differences (large missing sequence in RhD vs RhCE) & the size of the nucleotide sequences of intron 4 of the RhCE and RhD genes. it’s also nice to see it mentioned that others/other races outside of the “white” Europeans have more problems with what i’ll call false negative RhD test results. gotta look at the RhCE gene…looking for an RhC positive antigen test result which tends to coincide w/ an RhD false negative reading or rather an actual positive RhD antigen finding on the red blood cell surface.

  some important quotes: “Thereafter, the two-loci theory was advocated by Tippett (31), based on serological data. According to this model, RH genes consist of two structural genes: one encoding the RhD antigen, and the other encoding both the RhC/c and RhE/e antigens. Actually, two different RH-cDNAs (RHDand RHCE cDNAs) were cloned (2, 3, 15, 19, 20). By Southern analysis of genomic DNA, Colin et al. (1) indicated that two highly homologous genes were present in RhD-positive individuals, but that only one was present in RhD negative individuals. Absence of the RHD gene in RhD-negative individuals was confirmed after cloning of the RHD-cDNA (2, 3). These reports are compatible with the two-loci theory.”

  “The present data, however, demonstrated the normal RHD gene in 36 (27.7%) of 130 RhD-negative Japanese donors. We used every discretion in determining the RhD-negative phenotypes for excluding partial D, Du, or Del antigen. All of these RhD-negative donors with the RHD gene showed the CC or Cc phenotypes, but not the cc phenotype. These results suggest that there is some relationship between the RHD gene and the RhC phenotypes in RhD-negative individuals.”

  “With due regard to the percentage (69.2%) of the presence of RHD gene in the RhD-negative and RhC-positive individuals, the positive ratio of the RHD gene in Japanese RhD negatives is estimated to be 12.5%.”

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