New Study: SARS-CoV-2 and mutation RT-qPCR test positivity correlation with ABO and Rh blood types

The study below was published 8 June 2022.

SARS-CoV-2 and mutation RT-qPCR test positivity correlation with ABO and Rh blood types

Here are some highlights:

Studies show that there may be a relationship between ABO blood type and SARS-CoV-2 transmission. It was aimed to determine by investigating the blood type of patients whose one-step reverse transcription and real-time polymerase chain reaction (RT-qPCR) test were positive for SARS-CoV-2. ABO and Rh blood types of individuals whose RT-qPCR test was positive for SARS-CoV-2 were examined and an evaluation was made to identify whether there was a relationship between them or not. The blood type data of 44.928 SARS-CoV-2 positive RT-qPCR test results have been obtained. 17.656 (39.29%) were delta, 8048 (17.91%) were alpha, 800 (1.78%) were beta, and 3000 (6.67%) were omicrons while 15.424 (34.33%) SARS-CoV-2 positive mutation was found to be negative. Our study suggests that O and Rh (−) blood types may provide protection against delta, AB and Rh (+) blood types may hinder omicron infection while A and Rh (+) blood types may be more vulnerable to alpha and delta while B and Rh (+) are more sensitive to beta mutation. The molecular mechanism underlying the relationship between blood types and SARS-CoV-2 infection needs further molecular studies and multi-centered studies.

O and Rh-negative blood types may already have COVID-19 antibodies

In our study, it was observed that type A blood has the most SARS-CoV-2 mutation positivity in the distribution of SARS-CoV-2 positive mutation rates according to blood types since it was the most common blood type in our country. In addition, although the AB blood type is the least common blood type in our country, the rate of positivity increased rapidly as the L452R mutation became widespread. The positivity of the second common blood type in our country, O type, started to decrease as the L452 mutation became widespread. The SARS-CoV-2 positivity rate of Rh (D) (+) blood type increased in alpha mutation. SARS-CoV-2 positivity of the Rh (D) (−) blood type is more common in cases where there is no mutation.

O and Rh (D) (−) blood types may provide protection against delta mutation, AB and Rh (D) (+) blood types may hinder omicron infection while A and Rh (D) (+) blood types may be more vulnerable to alpha mutation and delta mutation and B and Rh(D) (+) are more sensitive to beta mutation based on the findings of our study.

See the study:

https://onlinelibrary.wiley.com/doi/10.1002/jmv.27923

Rh negative blood and COVID-19