What is cisAB?

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UPDATE:

CAN A BLOOD TYPE AB/O COUPLE HAVE AB AND O CHILDREN?

According to the blood type calculator, an AB and O couple can only have children who are either A or B.
The genotypes for both would be AB and OO, so with the O being recessive, only either the A or B can be passed on from the AB partner and the O would not show up in the phenotype.
So how come several AB and O couples have found me to alert me that they have children who are both phenotype AB and O?

The allele which they carry is called cisAB where both, the A and the B is being encoded into one allele and in their case their phenotype is in fact AB while their genotype would be cisAB/O.

In that case, a cisAB/O and O/O couple can only produce cisAB/O and O/O children meaning their offspring´s phenotype can only be AB or O, but never A or B.

rare blood type cisAB

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3 Comments

  1. Jenny Thompson August 14, 2015 Reply

    My grandmother was cis AB- I always knew she was special just not quite how special.She had 3 positive children long before Rhogam two O+ daughters and an AB+ son.

  2. A June 21, 2019 Reply

    I have. AB+ blood and have a daughter and a son with O+ blood. I am also 1/4 Japanese/Korean.

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