Diagram of the RHD and RHCE genes. The ten RHD exons are shown as white boxes, and the RHCE as grey. A). RHD and RHCE genes responsible for the common D, C, c, E and e antigen polymorphisms. B). Altered RHD and C). Altered RHCE genes indicating the changes often found in African-Americans that complicate transfusion, especially for sickle cell patients.
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This is now well established by genomic analysis. I have been reading Chapter 4 of Brian Sykes “The Seven daughters of Eve” (2001). He states that “finding DNA in mitochondria at all was a big surprise” and that “mitochondrial genes hold the code for the oxygen-capturing genes that do the work in mitochondria”….and much more. I speculate that this may be a significant clue in the great RH mystery. What if the gene deletions were caused by oxygen deprivation?
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This is now well established by genomic analysis. I have been reading Chapter 4 of Brian Sykes “The Seven daughters of Eve” (2001). He states that “finding DNA in mitochondria at all was a big surprise” and that “mitochondrial genes hold the code for the oxygen-capturing genes that do the work in mitochondria”….and much more. I speculate that this may be a significant clue in the great RH mystery. What if the gene deletions were caused by oxygen deprivation?
https://pubmed.ncbi.nlm.nih.gov/22287136/ for reading on epigenetics and Mitochondrial DNA