The Rh blood group antigens derive from 2 genes, RHD and RHCE, that are located at chromosomal position 1p34.1-1p36 (chromosome 1, short arm, region 3, band 4, subband 1, through band 6). In whites, a cde haplotype with a deletion of the whole RHD gene occurs with a frequency of approximately 40%. The relative position of the 2 RH genes and the location of the RHD deletion was previously unknown. A model has been developed for the RH locus using RHD- and RHCE-related nucleotide sequences deposited in nucleotide sequence databases along with polymerase chain reaction (PCR) and nucleotide sequencing. The open reading frames of both RH genes had opposite orientations. The 3′ ends of the genes faced each other and were separated by about 30 000 base pair (bp) that contained the SMP1 gene. The RHD gene was flanked by 2 DNA segments, dubbed Rhesus boxes, with a length of approximately 9000 bp, 98.6% homology, and identical orientation. The Rhesus box contained the RHD deletion occurring within a stretch of 1463 bp of identity. PCR with sequence-specific priming (PCR-SSP) and PCR with restriction fragment length polymorphism (PCR-RFLP) were used for specific detection of the RHD deletion. The molecular structure of the RH gene locus explains the mechanisms for generating RHD/RHCE hybrid alleles and the RHD deletion. Specific detection of the RHD(-) genotype is now possible. (Blood. 2000;95:3662-3668)
https://pubmed.ncbi.nlm.nih.gov/10845894/
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This is a world class piece of science ! However, it does not tell us how the RHD gene deletion occurred, when or where. I think that it is also significant in that it tells us that “not all Rh negs” are genetically identical…but that we have many sub-types and variants. I wish we could get more analysis and detail on that, since it might shed light on the when and where questions, and explain the very uneven global distributions of RH Neg.
Gene deletion is not as simple to understand as Mendelian analysis..but it can and will tell us much more.
When? Mike something may be happening. So many odd coincidences…really freaking me out!!!! Lets try to focus on why we have survived? The reason? The collective consciousness we share? I feel it in my soul!!! Something is about to happen! Soon, something that physically or mentally will be disturbing? I’m not able to discern if its a group, or me…I’m not that advanced!!! But put it out that we have to conglomerate, protect and watch! You know far sure I can be dramatic, but also know through personal emails I’m honest, and have The RH abilities we share that I’ve shown to be authentic….so however you wish to “warn” others? I’m sure you can do it with your particular brand of magic…but listen…an Event will cause distress or harm to our kind….refocus!meditate in nature! Listen to the message!!! And be safe, ok? Time is only an illusion? Prepare, something negative will happen soon! So lets focus on our Existence, and prevent extermination! That’s what I know…how? Not sure, but I’m certain, so listen please! Thank you for your research and topics…not nuts, just an RH negative…ok?