It is most frequent in Rh(D) negative women in general.
Female patients have significantly higher frequency of Rh negative, particularly O negative. This study will help in making public health policies.
The irregular antibody production for β-thalassemic children with long-term transfusion may have some relevance with Rh factor genotypes and thalassemia genetic mutations. This study possesses a certain significance for effective prevention of RBC alloimmune response of β-thalassemia children and improvement of efficacy and safety of clinical transfasion blood.