Weak D, Partial D and Del

Rhesusnegative.net

3 years ago

A). Weak D phenotypes. Amino acid changes that cause weak D expression, shown as circles, are located predominantly in transmembrane and cytoplasmic regions. Weak D Type 1 (V270G) predominates in Europeans, as well as Type 2 and Type 3, which together represent the majority of weak D, are indicated.

B). Partial D phenotypes. Amino acid changes that cause some partial D phenotyes are predicted to be located in the extracellular loops. The DNB mutation is frequent in Europeans.

C). Del phenotypes. Amino acid changes that severely reduce the quantity of RhD resulting in RBCs that type serologically D-negative are shown. The scribble line indicates loss of the 3′ region, characteristic of Asian mutations, and the European M295I mutation is shown in transmembrane nine.