Currently, the clinical use of sweat as biofluid is limited. The collection of sweat and its analysis for determining ethanol, drugs, ions, and metals have been encompassed in this review article to assess the merits of sweat compared to other biofluids, for example, blood or urine. Moreover, sweat comprises various biomarkers of different diseases including cystic fibrosis and diabetes. Additionally, the normalization of sampled volume of sweat is also necessary for getting efficient and useful results.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4369929/
Based on sweat analysis, advancements in the genomics and proteomics have enormously contributed to the field of metabolomics and the systems biology. The metabolisms of the macromolecules in sweat glands produce lower molecular weight metabolites, such as the conversion of proteins to peptides or amino acids. Since, metabolomics deals with measurements of both precursor and metabolites, sweat can be used as a biofluid, in addition to blood and urine, to explore biomarkers for various diseases. Subsequently, these discoveries help in exploring effective therapeutic moieties. Since sweat consists of various biomarkers, these biomarkers have played an excellent role in diagnosis of cancer, diabetes, schizophrenia, and cystic fibrosis. Conclusively, sweat can be used as a promising biofluid for disease diagnosis and drug analysis.
Lactic acidosis, which occurs when there’s too much lactic acid in your body. Causes can include chronic alcohol use, heart failure, cancer, seizures, liver failure, prolonged lack of oxygen, and low blood sugar. Even prolonged exercise can lead to lactic acid buildup.
Source: Healthline