The Rh Negative Blog

Which blood types are least impacted by cholera?

Study may explain why people with type O blood more likely to die of cholera Cholera; toxin more potent in people with most common blood type

Cholera is an infectious disease that causes severe watery diarrhea, which can lead to dehydration and even death if untreated. It is caused by eating food or drinking water contaminated with a bacterium called Vibrio cholerae.

Unfortunately, there is no data available regarding Rh(D) negative frequencies among patients and victims.

Group A and B make people more resistant to cholera, while AB confers the most:

Taken together, these results provide very convincing evidence that cholera toxin exerts a more potent effect on cells expressing the blood type O-associated glycan. This fits with the epidemiologic observation that blood type O only impacts disease severity, but not the risk of infection. However, this work still does not identify the precise mechanism by which cholera toxin induces a stronger response in the type O cells. In fact, a surprising finding in this study was that the greater effect of cholera toxin in blood group O-derived cells did not appear to be linked to the amount of toxin binding to cells, which was similar in both the type A- and type O-derived cells.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4973168/

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